Photodynamic Therapy Targeted to Pathogens

Vascular-Targeted Photodynamic Therapy (VTP)

Photodynamic therapy: a targeted therapy in periodontics.

The oral cavity is colonized by a large number and highly diversified communities of micro-organisms. Bacterial biofilm present on tooth or root surface is a major cause of gingivitis and periodontitis. Chemical antimicrobial agents are widely used in prophylactic and therapeutic regimens for dental plaque related diseases, which are among the most common human infections. As these agents are d...

Resistance to HER2-targeted therapy

Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...

Somatostatin Analogues for Receptor Targeted Photodynamic Therapy

Photodynamic therapy (PDT) is an established treatment modality, used mainly for anticancer therapy that relies on the interaction of photosensitizer, light and oxygen. For the treatment of pathologies in certain anatomical sites, improved targeting of the photosensitizer is necessary to prevent damage to healthy tissue. We report on a novel dual approach of targeted PDT (vascular and cellular ...

V ascular targeted photodynamic therapy ( VTP )

Introduction Studies in our laboratory focus on development of vascular targeted photodynamic therapy (VTP) based on bacteriochlorophyll derivatives as photosensitizer drugs, elucidation of its mechanism of action and development of new applications for photodynamic therapy (PDT) such as treatment of Extrauterine Pregnancy (EUP). These studies are in collaboration with Prof. Avigdor Scherz Dept...